Oxidative stress might be a mechanism connected with the decreased alpha 7 nicotinic receptor influenced by high-concentration of fluoride in SH-SY5Y neuroblastoma cells.

@article{Gao2008OxidativeSM,
  title={Oxidative stress might be a mechanism connected with the decreased alpha 7 nicotinic receptor influenced by high-concentration of fluoride in SH-SY5Y neuroblastoma cells.},
  author={Q. Gao and Yanjie Liu and Z. Guan},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2008},
  volume={22 4},
  pages={
          837-43
        }
}
  • Q. Gao, Yanjie Liu, Z. Guan
  • Published 2008
  • Chemistry, Medicine
  • Toxicology in vitro : an international journal published in association with BIBRA
  • The possible mechanism concerning decreased alpha 7 nicotinic acetylcholine receptor (nAChR) influenced by fluorosis was investigated. SH-SY5Y cells were exposed to fluoride within the range of 0.05-5 mM [corrected] or ferrous iron (1-100 mM) [corrected] a free radical inducer. The levels of alpha 7 nAChR expression, lipid peroxidation and protein oxidation were detected. The results showed that both high-concentrations of fluoride and ferrous iron induced increased levels of lipid peroxidation… CONTINUE READING
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    References

    SHOWING 1-10 OF 47 REFERENCES
    Selective decreases of nicotinic acetylcholine receptors in PC12 cells exposed to fluoride.
    • 26
    [Fluorosis on expression of nicotinic acetylcholine receptors in protein and gene levels in human SH-SY5Y neuroblastoma cells].
    • 3
    • Highly Influential
    Reduced expression of neuronal nicotinic acetylcholine receptors during the early stages of damage by oxidative stress in PC12 cells
    • 35
    • Highly Influential
    Chronic fluoride toxicity decreases the number of nicotinic acetylcholine receptors in rat brain.
    • 66
    Oxidative damage to mitochondria is a preliminary step to caspase-3 activation in fluoride-induced apoptosis in HL-60 cells.
    • 208
    α7 Nicotinic receptor-mediated protection against ethanol-induced oxidative stress and cytotoxicity in PC12 cells
    • 45
    Alterations in drug metabolising enzymes and lipid peroxidation in different rat tissues by fluoride.
    • 28
    Changed cellular membrane lipid composition and lipid peroxidation of kidney in rats with chronic fluorosis
    • 113