Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytes.

@article{Suematsu2003OxidativeSM,
  title={Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytes.},
  author={Nobuhiro Suematsu and Hiroyuki Tsutsui and Jing Wen and Dongchon Kang and Masaki Ikeuchi and Tomomi Ide and Shunji Hayashidani and Tetsuya Shiomi and Toru Kubota and Naotaka Hamasaki and Akira Takeshita},
  journal={Circulation},
  year={2003},
  volume={107 10},
  pages={1418-23}
}
BACKGROUND Tumor necrosis factor-alpha (TNF-alpha) and angiotensin II (Ang II) are implicated in the development and further progression of heart failure, which might be, at least in part, mediated by the production of reactive oxygen species (ROS). However, the cause and consequences of this agonist-mediated ROS production in cardiac myocytes have not been well defined. Recently, we demonstrated that increased ROS production was associated with mitochondrial DNA (mtDNA) damage and dysfunction… CONTINUE READING

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