Oxidative stress mediates cardiac infarction aggravation induced by intermittent hypoxia

@article{Ramond2013OxidativeSM,
  title={Oxidative stress mediates cardiac infarction aggravation induced by intermittent hypoxia},
  author={A. Ramond and D. Godin-Ribuot and C. Ribuot and P. Totoson and I. Koritchneva and S. Cachot and P. L{\'e}vy and M. Joyeux-faure},
  journal={Fundamental \& Clinical Pharmacology},
  year={2013},
  volume={27}
}
We have previously shown that chronic intermittent hypoxia (IH), a component of the obstructive sleep apnea syndrome, increases heart sensitivity to infarction. We investigate here the deleterious mechanisms potentially involved in the IH‐induced infarction aggravation, investigating the role of oxidative stress. Male Wistar rats were subjected to chronic IH or normoxia (N). IH consisted of repetitive 1‐min cycles (30 s with inspired O2 fraction 5% followed by 30 s normoxia) and was applied for… Expand
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