Oxidative stress-mediated inhibition of brain creatine kinase activity by methylmercury.

@article{Glaser2010OxidativeSI,
  title={Oxidative stress-mediated inhibition of brain creatine kinase activity by methylmercury.},
  author={Viviane Glaser and Guilhian Leipnitz and Marcos Raniel Straliotto and Jade de Oliveira and Vanessa Valgas dos Santos and Cl{\'o}vis Milton Duval Wannmacher and Andreza Fabro de Bem and Jo{\~a}o Batista T Rocha and Marcelo Farina and Alexandra Latini},
  journal={Neurotoxicology},
  year={2010},
  volume={31 5},
  pages={454-60}
}
Methylmercury (MeHg), a potent neurotoxicant, easily passes through the blood-brain barrier and accumulates in brain causing severe irreversible damage. However, the underlying neurotoxic mechanisms elicited by MeHg are still not completed defined. In this study, we aimed to investigate the in vitro toxic effects elicited by crescent concentrations (0-1500 microM) of MeHg on creatine kinase (CK) activity, thiol content (NPSH) and protein carbonyl content (PCC) in mouse brain preparations. In… CONTINUE READING

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