Oxidative stress is responsible for mitochondrial permeability transition induction by salicylate in liver mitochondria.

@article{Battaglia2005OxidativeSI,
  title={Oxidative stress is responsible for mitochondrial permeability transition induction by salicylate in liver mitochondria.},
  author={Valentina Battaglia and Mauro Salvi and Antonio Toninello},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 40},
  pages={
          33864-72
        }
}
The interaction of salicylate with the respiratory chain of liver mitochondria generates hydrogen peroxide and, most probably, other reactive oxygen species, which in turn oxidize thiol groups and glutathione. This oxidative stress, confirmed by the prevention of action by antioxidant agents, leads to the induction of the mitochondrial permeability transition in the presence of Ca2+. This phenomenon induces further increase of oxidative damage resulting in impairment of oxidative… CONTINUE READING
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