Oxidative stress is closely associated with tumor angiogenesis of hepatocellular carcinoma

  title={Oxidative stress is closely associated with tumor angiogenesis of hepatocellular carcinoma},
  author={Masayasu Jo and Taichiro Nishikawa and Tomoki Nakajima and Yoshihisa Okada and Kanji Yamaguchi and Hironori Mitsuyoshi and Kohichiroh Yasui and Masahito Minami and Masaki Iwai and Keizo Kagawa and Yoshito Itoh and Toshikazu Yoshikawa},
  journal={Journal of Gastroenterology},
Oxidative stress (OS) plays an important role in the progression of chronic liver disease and hepatocarcinogenesis. However, the role of OS in the progression of hepatocellular carcinoma (HCC) is unclear. The aim of this study was to assess whether OS promotes angiogenesis in HCC. The expressions of vascular endothelial growth factor (VEGF), VEGF receptor2 (VEGFR2), and phosphorylated Akt were assessed, and microvessel density (MVD) and the cancer-associated fibroblast (CAF) population were… CONTINUE READING


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