Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease.

@article{Mota2015OxidativeSI,
  title={Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease.},
  author={Sandra I. Mota and Rui O Costa and Ildete Lu{\'i}sa Ferreira and Isabel Santana and Gladys L. Caldeira and Carmela Padovano and Ana Catarina R G Fonseca and In{\^e}s Baldeiras and Catarina Cunha and Liliana Letra and Catarina Resende de Oliveira and Cl{\'a}udia Maria F. Pereira and A Cristina Rego},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1852 7},
  pages={1428-41}
}
Oxidative stress and endoplasmic reticulum (ER) stress have been associated with Alzheimer's disease (AD) progression. In this study we analyzed whether oxidative stress involving changes in Nrf2 and ER stress may constitute early events in AD pathogenesis by using human peripheral blood cells and an AD transgenic mouse model at different disease stages. Increased oxidative stress and increased phosphorylated Nrf2 (p(Ser40)Nrf2) were observed in human peripheral blood mononuclear cells (PBMCs… CONTINUE READING
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