Oxidative stress induction as a cause of Ba2+-dependent fungicidal action of UMP-derivative on the yeast Shizosaccharomyces pombe.

@article{Tanaka2003OxidativeSI,
  title={Oxidative stress induction as a cause of Ba2+-dependent fungicidal action of UMP-derivative on the yeast Shizosaccharomyces pombe.},
  author={Toshio Tanaka and Y. Usuki},
  journal={Journal of bioscience and bioengineering},
  year={2003},
  volume={96 5},
  pages={
          500-2
        }
}
A UMP-derivative, uridine 5'-hexadecylphosphate (UMPC16), exhibited a fungicidal action against various yeast strains including the fission yeast Schizosaccharomyces pombe in combination with Ba2+ ion. UMPC16 accelerated reactive oxygen species (ROS) generation in medium with Ba2+ ion in a dose- and time-dependent manner. Additional supplementation of Ca2+ ion into medium could suppress such a combined fungicidal action due to oxidative stress induction. 
View on PubMed
doi.org
2 Citations

2 Citations

Citation Type

Citation Type

Synergistic fungicidal activity of Cu(2+) and allicin, an allyl sulfur compound from garlic, and its relation to the role of alkyl hydroperoxide reductase 1 as a cell surface defense in Saccharomyces cerevisiae.
Oxidative stress-dependent inhibition of yeast cell growth by farnesylamine and its possible relation to amine oxidase in the mitochondrial fraction.

References

SHOWING 1-10 OF 14 REFERENCES
Farnesol-induced generation of reactive oxygen species via indirect inhibition of the mitochondrial electron transport chain in the yeast Saccharomyces cerevisiae.
Depletion of glutathione as a cause of the promotive effects of polygodial, a sesquiterpene on the production of reactive oxygen species in Saccharomyces cerevisiae.
Inhibitory effects of nucleoside 5'-alkylphosphates on sexual agglutination in Saccharomyces cerevisiae.
Farnesol‐induced generation of reactive oxygen species dependent on mitochondrial transmembrane potential hyperpolarization mediated by F0F1‐ATPase in yeast
Alkyl hydroperoxide reductase 1 protects Saccharomyces cerevisiae against metal ion toxicity and glutathione depletion.
Irreversible deacylation of plasma membrane phospholipids by the combined action of Mg2+ and a long-chain acyl-CoA synthetase inhibitor in Saccharomyces cerevisiae.
Evaluation of adenosine 5'-hexadecylphosphate as an inhibitor of acyl-CoA synthetase isozyme functional for phospholipid reconstitution in the yeast Saccharomyces cerevisiae.
Oxidative mechanisms in the toxicity of metal ions.
Long-chain alkyl ester of AMP acts as an antagonist of glucose-induced signal transduction that mediates activation of plasma membrane proton pump in Saccharomyces cerevisiae.
Effects of adenosine 5′‐phosphate esters with lipoid hydroxy compounds (adenosine nucleolipids) on the activity of enzymes of cyclic AMP system
...
1
2
...