Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling.

@article{Byon2008OxidativeSI,
  title={Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling.},
  author={Chang Hyun Byon and Amjad Javed and Qun Dai and John C Kappes and Thomas L. Clemens and Victor M. Darley-Usmar and J. M. Mcdonald and Yabing Chen},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 22},
  pages={15319-27}
}
Oxidative stress plays a critical role in the pathogenesis of atherosclerosis including the formation of lipid laden macrophages and the development of inflammation. However, oxidative stress-induced molecular signaling that regulates the development of vascular calcification has not been investigated in depth. Osteogenic differentiation of vascular smooth muscle cells (VSMC) is critical in the development of calcification in atherosclerotic lesions. An important contributor to oxidative stress… CONTINUE READING
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Runx2 Regulates VSMC Calcification

  • K. Radcliff, T. B. Tang, +4 authors Y. Tintut
  • Circ. Res
  • 2005

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