Oxidative stress induces mitochondrial fragmentation in frataxin-deficient cells.

@article{Lefevre2012OxidativeSI,
  title={Oxidative stress induces mitochondrial fragmentation in frataxin-deficient cells.},
  author={Sophie Denise Lefevre and Dominika Sliwa and Pierre Rustin and Jean-Michel Camadro and Renata Santos},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={418 2},
  pages={336-41}
}
Friedreich ataxia (FA) is the most common recessive neurodegenerative disease. It is caused by deficiency in mitochondrial frataxin, which participates in iron-sulfur cluster assembly. Yeast cells lacking frataxin (Δyfh1 mutant) showed an increased proportion of fragmented mitochondria compared to wild-type. In addition, oxidative stress induced complete fragmentation of mitochondria in Δyfh1 cells. Genetically controlled inhibition of mitochondrial fission in these cells led to increased… CONTINUE READING
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