Oxidative stress induces extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase in cystic fibrosis lung epithelial cells: Potential mechanism for excessive IL-8 expression.

@article{Boncoeur2008OxidativeSI,
  title={Oxidative stress induces extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase in cystic fibrosis lung epithelial cells: Potential mechanism for excessive IL-8 expression.},
  author={Emilie Boncoeur and Vinciane Saint Criq and Elise Bonvin and Telma Roque and Alexandra Henrion-Caude and Dieter C. Gruenert and Annick Cl{\'e}ment and J. -P. Jacquot and Olivier Tabary},
  journal={The international journal of biochemistry & cell biology},
  year={2008},
  volume={40 3},
  pages={432-46}
}
Cystic fibrosis (CF) is a lethal disease caused by defective function of the cftr gene product, the CF transmembrane conductance regulator (CFTR) that leads to oxidative damage and excessive inflammatory response in lungs of CF patients. We here report the effects of oxidative stress (hyperoxia, 95% O(2)) on the expression of pro-inflammatory interleukin (IL)-8 and CXCR1/2 receptors in two human CF lung epithelial cell lines (IB3-1, with the heterozygous F508del/W1282X mutation and CFBE41o… CONTINUE READING
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