Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands

  title={Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands},
  author={Xiaoxia Z. West and Nikolay L. Malinin and Alona A. Merkulova and Mira Tischenko and Bethany A Kerr and Ernest C. Borden and Eugene A. Podrez and Robert G Salomon and Tatiana V. Byzova},
Reciprocity of inflammation, oxidative stress and neovascularization is emerging as an important mechanism underlying numerous processes from tissue healing and remodelling to cancer progression. Whereas the mechanism of hypoxia-driven angiogenesis is well understood, the link between inflammation-induced oxidation and de novo blood vessel growth remains obscure. Here we show that the end products of lipid oxidation, ω-(2-carboxyethyl)pyrrole (CEP) and other related pyrroles, are generated… CONTINUE READING
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