Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands

@article{West2010OxidativeSI,
  title={Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands},
  author={Xiaoxia Z. West and N. Malinin and A. Merkulova and Mira Tischenko and B. Kerr and E. Borden and E. Podrez and R. G. Salomon and T. Byzova},
  journal={Nature},
  year={2010},
  volume={467},
  pages={972-976}
}
Reciprocity of inflammation, oxidative stress and neovascularization is emerging as an important mechanism underlying numerous processes from tissue healing and remodelling to cancer progression. Whereas the mechanism of hypoxia-driven angiogenesis is well understood, the link between inflammation-induced oxidation and de novo blood vessel growth remains obscure. Here we show that the end products of lipid oxidation, ω-(2-carboxyethyl)pyrrole (CEP) and other related pyrroles, are generated… Expand
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