Oxidative stress induces DNA damage and inhibits the repair of DNA lesions induced by N-acetoxy-2-acetylaminofluorene in human peripheral mononuclear leukocytes.

@article{Pero1990OxidativeSI,
  title={Oxidative stress induces DNA damage and inhibits the repair of DNA lesions induced by N-acetoxy-2-acetylaminofluorene in human peripheral mononuclear leukocytes.},
  author={Ronald W. Pero and Marshall W. Anderson and Glenn A Doyle and Colleen H. Anna and F. Romagna and Martin Markowitz and Carl Bryngelsson},
  journal={Cancer research},
  year={1990},
  volume={50 15},
  pages={4619-25}
}
Human mononuclear leukocytes were exposed to prooxidants such as H2O2, phorbol-12-myristate-13-acetate, and 4-nitroquinoline-N-oxide, and the effects on induction of DNA damage and repair were evaluated. ADP ribosylation was activated by prooxidant exposure and the response was bimodal with peaks of activation occurring at about 30 min and 4-5 h. Other evidence for prooxidant-induced DNA damage was provided by nucleoid sedimentation assays. Unscheduled DNA synthesis (UDS) was only slightly… CONTINUE READING

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