Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier

@article{GilgunSherki2001OxidativeSI,
  title={Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier},
  author={Y. Gilgun-Sherki and E. Melamed and D. Offen},
  journal={Neuropharmacology},
  year={2001},
  volume={40},
  pages={959-975}
}
  • Y. Gilgun-Sherki, E. Melamed, D. Offen
  • Published 2001
  • Medicine, Biology
  • Neuropharmacology
  • Oxidative stress (OS) has been implicated in the pathophysiology of many neurological, particularly neurodegenerative diseases. OS can cause cellular damage and subsequent cell death because the reactive oxygen species (ROS) oxidize vital cellular components such as lipids, proteins, and DNA. Moreover, the brain is exposed throughout life to excitatory amino acids (such as glutamate), whose metabolism produces ROS, thereby promoting excitotoxicity. Antioxidant defense mechanisms include removal… CONTINUE READING
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