Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier

@article{GilgunSherki2001OxidativeSI,
  title={Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier},
  author={Yossi Gilgun-Sherki and Eldad Melamed and Daniel Offen},
  journal={Neuropharmacology},
  year={2001},
  volume={40},
  pages={959-975}
}
Oxidative stress (OS) has been implicated in the pathophysiology of many neurological, particularly neurodegenerative diseases. OS can cause cellular damage and subsequent cell death because the reactive oxygen species (ROS) oxidize vital cellular components such as lipids, proteins, and DNA. Moreover, the brain is exposed throughout life to excitatory amino acids (such as glutamate), whose metabolism produces ROS, thereby promoting excitotoxicity. Antioxidant defense mechanisms include removal… 
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