Oxidative stress-induced insulin resistance in rat skeletal muscle: role of glycogen synthase kinase-3.

  title={Oxidative stress-induced insulin resistance in rat skeletal muscle: role of glycogen synthase kinase-3.},
  author={Betsy B. Dokken and Vitoon Saengsirisuwan and John S. Kim and Mary K. Teachey and Erik J. Henriksen},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={294 3},
Oxidative stress can contribute to the multifactorial etiology of whole body and skeletal muscle insulin resistance. No investigation has directly assessed the effect of an in vitro oxidant stress on insulin action in intact mammalian skeletal muscle. Therefore, the purpose of the present study was to characterize the molecular actions of a low-grade oxidant stress (H(2)O(2)) on insulin signaling and glucose transport in isolated skeletal muscle of lean Zucker rats. Soleus strips were incubated… 

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