Oxidative stress-induced insulin resistance in rat skeletal muscle: role of glycogen synthase kinase-3.
@article{Dokken2008OxidativeSI, title={Oxidative stress-induced insulin resistance in rat skeletal muscle: role of glycogen synthase kinase-3.}, author={Betsy B. Dokken and Vitoon Saengsirisuwan and John S. Kim and Mary K. Teachey and Erik J. Henriksen}, journal={American journal of physiology. Endocrinology and metabolism}, year={2008}, volume={294 3}, pages={ E615-21 } }
Oxidative stress can contribute to the multifactorial etiology of whole body and skeletal muscle insulin resistance. No investigation has directly assessed the effect of an in vitro oxidant stress on insulin action in intact mammalian skeletal muscle. Therefore, the purpose of the present study was to characterize the molecular actions of a low-grade oxidant stress (H(2)O(2)) on insulin signaling and glucose transport in isolated skeletal muscle of lean Zucker rats. Soleus strips were incubated…
97 Citations
Oxidant stress-induced loss of IRS-1 and IRS-2 proteins in rat skeletal muscle: role of p38 MAPK.
- BiologyFree radical biology & medicine
- 2009
Attenuation of oxidant-induced muscle insulin resistance and p38 MAPK by exercise training.
- BiologyFree radical biology & medicine
- 2009
Oxidative stress-induced insulin resistance in skeletal muscle cells is ameliorated by gamma-tocopherol treatment
- Medicine, BiologyEuropean journal of nutrition
- 2008
High-dose (200 µM) GT treatment ameliorated oxidative stress-induced insulin resistance in cultured rat L6 skeletal muscle cells.
Critical role of the transient activation of p38 MAPK in the etiology of skeletal muscle insulin resistance induced by low-level in vitro oxidant stress.
- Biology, MedicineBiochemical and biophysical research communications
- 2011
Exercise training attenuates oxidative stress and decreases p53 protein content in skeletal muscle of type 2 diabetic Goto-Kakizaki rats.
- BiologyFree radical biology & medicine
- 2011
Oxidative stress and the etiology of insulin resistance and type 2 diabetes.
- BiologyFree radical biology & medicine
- 2011
High-fat load: mechanism(s) of insulin resistance in skeletal muscle.
- BiologyInternational journal of obesity supplements
- 2012
These findings imply that obesity, or more likely the metabolic imbalance that causes obesity, leads to a progressive decline in mitochondrial function, eventually culminating in mitochondrial dissolution or mitoptosis, which places the etiology of insulin resistance in the context of cellular/mitochondrial bioenergetics and redox systems biology.
The lipid peroxidation end-product and oxidant 4-hydroxynonenal induces insulin resistance in rat slow-twitch skeletal muscle
- Biology, ChemistryArchives of physiology and biochemistry
- 2014
The lipid peroxidation end-product and oxidant 4-HNE induces insulin resistance of glucose transport activity in rat slow-twitch skeletal muscle, initially associated with impaired phosphorylation of AS160.
Skeletal muscle insulin resistance: role of mitochondria and other ROS sources.
- Biology, MedicineThe Journal of endocrinology
- 2017
It is concluded that the different pathways leading to insulin resistance may act synergistically because ROS production by mitochondria and other sources can result in mitochondrial dysfunction, which in turn can further increase ROS production leading to the establishment of a harmful positive feedback loop.
Effects of H2O2 on insulin signaling the glucose transport system in mammalian skeletal muscle.
- BiologyMethods in enzymology
- 2013
References
SHOWING 1-10 OF 41 REFERENCES
Oxidant stress and skeletal muscle glucose transport: roles of insulin signaling and p38 MAPK.
- BiologyFree radical biology & medicine
- 2006
Short-term in vitro inhibition of glycogen synthase kinase 3 potentiates insulin signaling in type I skeletal muscle of Zucker Diabetic Fatty rats.
- Biology, ChemistryMetabolism: clinical and experimental
- 2007
Role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes.
- Biology, MedicineCurrent drug targets
- 2006
It is clear from these studies that selectively targeting GSK-3 in skeletal muscle may be an important new strategy for the treatment of obesity-associated insulin-resistant states characterized by G SKS-3 overactivity in insulin-sensitive tissues.
Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle.
- Biology, MedicineDiabetes
- 2002
It is suggested that selective inhibition of GSK-3 has an impact on both GS and glucose uptake, including effects on insulin action, using mechanisms that differ from and are additive to those of insulin.
Exercise training and the antioxidant α-lipoic acid in the treatment of insulin resistance and type 2 diabetes
- Medicine, Biology
- 2006
Regulation of Glucose Transport and Glycogen Synthesis in L6 Muscle Cells during Oxidative Stress
- Biology, Computer ScienceThe Journal of Biological Chemistry
- 1999
Investigation of cellular mechanisms that participate in reducing insulin sensitivity in response to increased oxidant stress in skeletal muscle shows activation of the p38 MAP kinase pathway plays a central role in the oxidant-induced inhibition of insulin-regulated glucose transport, and unveils an important biochemical link between the classical stress-activated and insulin signaling pathways in skeletal Muscle.
Modulation of muscle insulin resistance by selective inhibition of GSK-3 in Zucker diabetic fatty rats.
- Biology, MedicineAmerican journal of physiology. Endocrinology and metabolism
- 2003
Results indicate that specific inhibition of GSK-3 enhances insulin action on glucose transport in skeletal muscle of the insulin-resistant ZDF rat, and this unique approach may hold promise as a pharmacological treatment against insulin resistance of skeletal muscle glucose disposal.
Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid.
- BiologyDiabetes
- 2001
In muscle, the major site of insulin-stimulated glucose disposal, one important effect of LA on the insulin-signaling cascade is to protect cells from oxidative stress-induced insulin resistance, indicating that in diabetic patients, alpha-lipoic acid improves skeletal muscle glucose transport.
Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo.
- Biology, MedicineDiabetes
- 2003
Novel substituted aminopyrimidine derivatives that inhibit human GSK-3 potently with at least 500-fold selectivity against 20 other protein kinases are described and suggested to be useful as acute-acting therapeutics for the treatment of the insulin resistance of type 2 diabetes.
Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats.
- Biology, ChemistryDiabetes
- 2002
Oral glucose tolerance tests and clamp studies in Zucker diabetic fatty rats suggest that GSK-3 inhibition may represent an important new therapeutic target for treatment of patients with type 2 diabetes.