Oxidative stress-induced cytotoxic and genotoxic effects of nano-sized titanium dioxide particles in human HaCaT keratinocytes.

@article{Jaeger2012OxidativeSC,
  title={Oxidative stress-induced cytotoxic and genotoxic effects of nano-sized titanium dioxide particles in human HaCaT keratinocytes.},
  author={Alexandra Jaeger and Dieter G. Weiss and Ludwig Jonas and Ralf Kriehuber},
  journal={Toxicology},
  year={2012},
  volume={296 1-3},
  pages={27-36}
}
Since nano-sized particles (NPs) are increasingly used in various fields of innovative biomedicine and industrial technologies, it is of importance to identify their potential human health risk. We investigated whether ROS-induced mitochondrial DNA damage is the mode of action of titanium dioxide-NPs (TiO2-NPs; ≤20 nm) to induce cytotoxic and genotoxic effects in human HaCaT keratinocytes in vitro. We showed that TiO2-NPs accumulate at the cell surface and are taken up by endocytosis… CONTINUE READING
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