Oxidative stress induced by microcystin-LR on PLHC-1 fish cell line.

  title={Oxidative stress induced by microcystin-LR on PLHC-1 fish cell line.},
  author={Mar{\'i}a Puerto and Silvia Pichardo and {\'A}ngeles Jos and Ana M Came{\'a}n},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  volume={23 8},
Increasing evidences suggest that oxidative stress may play a significant role in microcystins (MCs) toxicity not only in mammals, but also in fish. In this regard, many in vivo studies have been performed but little is still known about the alteration of oxidative stress biomarkers on fish cell lines so far. In this study, the toxic effects of MC-LR were investigated in the fish cell line PLHC-1, derived from a hepatocellular carninoma of the topminnow Poeciliosis lucida, after 48 h of… CONTINUE READING


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