Oxidative stress-induced JNK activation contributes to proinflammatory phenotype of aging diabetic mesangial cells.

@article{Wu2009OxidativeSJ,
  title={Oxidative stress-induced JNK activation contributes to proinflammatory phenotype of aging diabetic mesangial cells.},
  author={Jin Wu and Changlin Mei and Helen Vlassara and Gary E. Striker and Feng Zheng},
  journal={American journal of physiology. Renal physiology},
  year={2009},
  volume={297 6},
  pages={F1622-31}
}
Chronic inflammation and increased oxidative stress (OS) play an important role in diabetic nephropathy progression. Herein, we show that mesangial cells from streptozotocin-induced aging diabetic mice, a model of progressive diabetic nephropathy, exhibited increased OS and a proinflammatory phenotype characterized by elevated chemokines and ICAM-1 expression. This phenotypic change was consistent with the extensive inflammatory lesions present in aging diabetic kidneys and was not found in… CONTINUE READING

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Herein , we show that mesangial cells from streptozotocin - induced aging diabetic mice , a model of progressive diabetic nephropathy , exhibited increased OS and a proinflammatory phenotype characterized by elevated chemokines and ICAM-1 expression .
Herein , we show that mesangial cells from streptozotocin - induced aging diabetic mice , a model of progressive diabetic nephropathy , exhibited increased OS and a proinflammatory phenotype characterized by elevated chemokines and ICAM-1 expression .
Herein , we show that mesangial cells from streptozotocin - induced aging diabetic mice , a model of progressive diabetic nephropathy , exhibited increased OS and a proinflammatory phenotype characterized by elevated chemokines and ICAM-1 expression .
Herein , we show that mesangial cells from streptozotocin - induced aging diabetic mice , a model of progressive diabetic nephropathy , exhibited increased OS and a proinflammatory phenotype characterized by elevated chemokines and ICAM-1 expression .
Herein , we show that mesangial cells from streptozotocin - induced aging diabetic mice , a model of progressive diabetic nephropathy , exhibited increased OS and a proinflammatory phenotype characterized by elevated chemokines and ICAM-1 expression .
Herein , we show that mesangial cells from streptozotocin - induced aging diabetic mice , a model of progressive diabetic nephropathy , exhibited increased OS and a proinflammatory phenotype characterized by elevated chemokines and ICAM-1 expression .
Herein , we show that mesangial cells from streptozotocin - induced aging diabetic mice , a model of progressive diabetic nephropathy , exhibited increased OS and a proinflammatory phenotype characterized by elevated chemokines and ICAM-1 expression .
Herein , we show that mesangial cells from streptozotocin - induced aging diabetic mice , a model of progressive diabetic nephropathy , exhibited increased OS and a proinflammatory phenotype characterized by elevated chemokines and ICAM-1 expression .
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