Oxidative stress increases the risk of pancreatic β cell damage in chronic renal hypertensive rats

Abstract

Hypertension often occurs in conjunction with insulin resistance. The purpose of this study was to evaluate whether sustained renal hypertension increases the risk of diabetes mellitus in rats, and to define the underlying mechanisms. Two-kidney, one-clip hypertensive (2K1C) rats received captopril (50 mg/kg/day), α-lipoic acid (100 mg/kg/day), or vehicle… (More)
DOI: 10.14814/phy2.12900

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