Oxidative stress increases susceptibility of Mycobacterium tuberculosis to isoniazid.

  title={Oxidative stress increases susceptibility of Mycobacterium tuberculosis to isoniazid.},
  author={Vanja M Bulatovi{\'c} and Nancy L. Wengenack and James R. Uhl and Leslie J Hall and Glenn D. Roberts and Franklin R. Cockerill and Frank Rusnak},
  journal={Antimicrobial agents and chemotherapy},
  volume={46 9},
Isoniazid is a first-line antibiotic used in the treatment of infections caused by Mycobacterium tuberculosis. Isoniazid is a prodrug requiring oxidative activation by the catalase-peroxidase hemoprotein, KatG. Resistance to isoniazid can be obtained by point mutations in the katG gene, with one of the most common being a threonine-for-serine substitution at position 315 (S315T). The S315T mutation is found in more than 50% of isoniazid-resistant clinical isolates and results in an… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 14 extracted citations

Changes in vitamin C and oxidative stress status during the treatment of tuberculous meningitis.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease • 2013


Publications referenced by this paper.
Showing 1-10 of 49 references

Antimicrobial agents and susceptibility tests, p. 1606–1623

C. B. Inderlied, M. Salfinger
Manual of clinical microbiology, • 1999

Isoniazid oxidation by Mycobacterium tuberculosis KatG: a role for superoxide which correlates with isoniazid susceptibility

N. L. Wengenack, H. M. Hoard, F. Rusnak
J. Am. Chem • 1999

Similar Papers

Loading similar papers…