Oxidative stress increases susceptibility of Mycobacterium tuberculosis to isoniazid.

@article{Bulatovi2002OxidativeSI,
  title={Oxidative stress increases susceptibility of Mycobacterium tuberculosis to isoniazid.},
  author={Vanja M Bulatovi{\'c} and Nancy L. Wengenack and James R. Uhl and Leslie J Hall and Glenn D. Roberts and Franklin R. Cockerill and Frank Rusnak},
  journal={Antimicrobial agents and chemotherapy},
  year={2002},
  volume={46 9},
  pages={2765-71}
}
Isoniazid is a first-line antibiotic used in the treatment of infections caused by Mycobacterium tuberculosis. Isoniazid is a prodrug requiring oxidative activation by the catalase-peroxidase hemoprotein, KatG. Resistance to isoniazid can be obtained by point mutations in the katG gene, with one of the most common being a threonine-for-serine substitution at position 315 (S315T). The S315T mutation is found in more than 50% of isoniazid-resistant clinical isolates and results in an… CONTINUE READING

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