Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian lenses, and Abeta has toxic effects on lens epithelial cells.

Abstract

Many amyloid diseases are characterized by protein aggregations linked to oxidative stress. Such diseases including those of the brain, muscle, and blood vessels exhibit plaques containing beta-amyloid (Abeta). Here we demonstrate that Alzheimer's precursor protein (betaAPP) and A beta are present at low levels in normal lenses and increase in intact… (More)

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@article{Frederikse1996OxidativeSI, title={Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian lenses, and Abeta has toxic effects on lens epithelial cells.}, author={Peter H. Frederikse and Donita L. Garland and J. Samuel Zigler and Joram Piatigorsky}, journal={The Journal of biological chemistry}, year={1996}, volume={271 17}, pages={10169-74} }