Oxidative stress increases neurogenesis and oligodendrogenesis in adult neural progenitor cells.

  title={Oxidative stress increases neurogenesis and oligodendrogenesis in adult neural progenitor cells.},
  author={Cynthia P{\'e}rez Estrada and Ruxandra Covacu and Sreenivasa Raghavan Sankavaram and Mikael Svensson and Lou Brundin},
  journal={Stem cells and development},
  volume={23 19},
Hydrogen peroxide (H2O2) is a reactive oxygen species that is involved in immunity and neuroinflammation. Here, we investigated whether and how pathophysiological levels of H2O2 influenced the differentiation of neural progenitor cells (NPCs). H2O2 levels within the range measured at neuroinflammatory events were applied to rat primary NPC cultures during 24 h, and effects were assessed directly after exposure or in NPCs that were differentiated for 7 days after H2O2 removal. Exposed… CONTINUE READING
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