Oxidative stress in type 1 diabetes.

  title={Oxidative stress in type 1 diabetes.},
  author={Kathryn Haskins and Brenda Bradley and Katherine Powers and Valerie Fadok and Sonia Flores and Xiaofeng Ling and Subbiah Pugazhenthi and Jane Reusch and Jennifer A. Kench},
  journal={Annals of the New York Academy of Sciences},
We have been investigating the effects of preventing oxidative stress on pathogenesis and complications of type 1 diabetes in the NOD mouse model. Our studies have shown that damage caused by oxidative stress is higher in islets and vascular tissue of NOD mice than in nonautoimmune controls or a diabetes-resistant NOD mouse. In addition, phagocytic function and cytokine production by macrophages are aberrant in the NOD. We have demonstrated that treatment of prediabetic NOD mice for 2 weeks… CONTINUE READING

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