Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy.

@article{Stefanova2005OxidativeSI,
  title={Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy.},
  author={Nadia Stefanova and Markus Reindl and Manuela Neumann and Christian Haass and Werner Poewe and Philipp J Kahle and Gregor Karl Wenning},
  journal={The American journal of pathology},
  year={2005},
  volume={166 3},
  pages={869-76}
}
Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by parkinsonism unresponsive to dopaminergic therapy, cerebellar ataxia, and dysautonomia. Neuropathology shows a characteristic neuronal multisystem degeneration that is associated with widespread oligodendroglial alpha-synuclein (alpha-SYN) inclusions. Presently no animal model completely replicates the specific neuropathology of MSA. Here we investigated the behavioral and pathological features resulting… CONTINUE READING