Oxidative stress in the trabecular meshwork (Review).

@article{Zhao2016OxidativeSI,
  title={Oxidative stress in the trabecular meshwork (Review).},
  author={Jing Zhao and Shuang Wang and Wei Zhong and Ben Yang and Lixia Sun and Yajuan Zheng},
  journal={International journal of molecular medicine},
  year={2016},
  volume={38 4},
  pages={
          995-1002
        }
}
Glaucoma is the second leading cause of blindness worldwide and elevated intraocular pressure (IOP) is the most important risk factor. High IOP usually occurs as a result of an increase in aqueous humor outflow resistance at the trabecular meshwork (TM). An abnormal TM contributes to the development of glaucoma. Oxidative stress and vascular damage are considered two major cellular factors that lead to alterations in the TM. In this review, we discuss the findings related to oxidative damage to… 
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Oxidative stress and antioxidants in the trabecular meshwork
TLDR
The mechanisms of oxidative stress in the TM and treatment strategies for this condition, including strategies involving antioxidants, noncoding RNAs and exogenous compounds, are discussed and new targets for glaucoma prevention are suggested.
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The multiple cellular processes, which promote different risk factors in glaucoma including aging, oxidative stress, trabecular meshwork defects, glial activation response, neurodegenerative insults, and the altered regulation of immune response are summarized.
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TLDR
Prdx6 is proposed as a potential therapeutic target to guard the TM from oxidative-stress and age-dependent accumulation of ROS by balancing redox-homeostasis to prevent ocular disorders, like glaucoma.
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The aim of the present review was to discuss the recent findings regarding the major physiological functions of myocilin, such as intra- and extracellular proteolytic processes, and the risk factors associated with myOCilin and the development of glaucoma.
Homocysteine induces oxidative stress to damage trabecular meshwork cells
TLDR
Patients with primary open-angle glaucoma and senile cataracts were demonstrated to have increased concentrations of Hcy in the plasma and aqueous humor, demonstrating that Hcy may be a potential treatment target in patients with POAG.
Strategies to Reduce Oxidative Stress in Glaucoma Patients
TLDR
It is proven that antioxidants and ω-3/ω-6 fatty acids at the molecular level in the glaucomatous anterior and posterior eye segments may help regulating the intraocular pressure as well as protecting the retinal neurons against OS/NS in POAG.
Interplay between Oxidative Stress, Inflammation, and Amyloidosis in the Anterior Segment of the Eye; Its Pathological Implications
TLDR
It is found that there is no consensus about which factor is the first to cause amyloidosis, and there is an interplay among these factors forming a vicious cycle that leads to the loss of protein structure in ocular pathologies, and multifactorial therapies should be developed to avoid protein misfolding and to stop the progression of ocular Pathologies.
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TLDR
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TLDR
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TLDR
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