Oxidative stress in the infarcted heart: role of de novo angiotensin II production.

@article{Lu2004OxidativeSI,
  title={Oxidative stress in the infarcted heart: role of de novo angiotensin II production.},
  author={Li Lu and Mark T Quinn and Yao Sun},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={325 3},
  pages={943-51}
}
This study aimed to elucidate whether angiotensin (Ang) II generated de novo at the infarct site regulates the redox state of inflammatory cells participating in cardiac repair. On days 3-28 following ligation of the rat left coronary artery, we addressed at the infarct site: (a) the appearance and cellular origin of oxidative stress by monitoring the expression (mRNA and protein) of gp91phox (a subunit of superoxide producing NADPH oxidase) and the antioxidant superoxide dismutase (SOD… CONTINUE READING