Oxidative stress in the development, maintenance and resolution of paclitaxel-induced painful neuropathy

@inproceedings{Duggett2016OxidativeSI,
  title={Oxidative stress in the development, maintenance and resolution of paclitaxel-induced painful neuropathy},
  author={Natalie A. Duggett and Lisa A. Griffiths and Olivia E. McKenna and Vittorio de Santis and Nutcha Yongsanguanchai and Esther B. Mokori and Sarah J L Flatters},
  booktitle={Neuroscience},
  year={2016}
}
Paclitaxel is a first-line chemotherapeutic with the major dose-limiting side effect of painful neuropathy. Previous preclinical studies indicate mitochondrial dysfunction and oxidative stress are associated with this disorder; however no direct assessment of reactive oxygen species (ROS) levels and antioxidant enzyme activity in sensory neurons following paclitaxel has been undertaken. As expected, repeated low doses of systemic paclitaxel in rats induced long-lasting pain behaviour with a… CONTINUE READING
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