Oxidative stress in synapse development and function.

  title={Oxidative stress in synapse development and function.},
  author={Valerie J Milton and Sean T Sweeney},
  journal={Developmental neurobiology},
  volume={72 1},
Oxidative stress, caused by increased levels of reactive oxidative species (ROS), is considered a major contributor to the aging process. How oxidative stress may bring about changes to structures and function in the aging brain is poorly understood. Oxidative stress activates a number of cellular responses, including activation of the Jun-N-terminal kinase (JNK) pathway and autophagy. In addition to their pathological role, ROS also act as signaling molecules. ROS such as nitric oxide have a… CONTINUE READING