Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy.

@article{Kuwahara2010OxidativeSI,
  title={Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy.},
  author={Hirotomo Kuwahara and Tetsuro Horie and Shin Ishikawa and Chizuru Tsuda and Satoru Kawakami and Yoshihiro Noda and Takao Kaneko and Shoichi Tahara and Toshiaki Tachibana and Masataka Okabe and Judith Melki and Riya Takano and Toshihiko Toda and Daichi Morikawa and Hidetoshi Nojiri and Hisashi Kurosawa and Takuji Shirasawa and Takahiko Shimizu},
  journal={Free radical biology & medicine},
  year={2010},
  volume={48 9},
  pages={1252-62}
}
The increase in reactive oxygen species (ROS) levels that occurs during intense exercise has been proposed to be one of the major causes of muscle fatigue. In addition, the accumulation of cellular damage due to ROS is widely regarded to be one of the factors triggering age-related pathological conditions in skeletal muscle. To investigate the pathological significance of oxidative stress in skeletal muscle, we generated skeletal muscle-specific manganese superoxide dismutase-deficient (muscle… CONTINUE READING

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