Oxidative stress in mouse heart by antitumoral drugs: a comparative study of doxorubicin and mitoxantrone.

@article{Arnaiz1993OxidativeSI,
  title={Oxidative stress in mouse heart by antitumoral drugs: a comparative study of doxorubicin and mitoxantrone.},
  author={S Lores Arnaiz and Susana Francisca Llesuy},
  journal={Toxicology},
  year={1993},
  volume={77 1-2},
  pages={31-8}
}
Doxorubicin and mitoxantrone were given to mice in a single dose of 15 mg/kg body wt (i.p.). 'In situ' heart spontaneous chemiluminescence, hydroperoxide-initiated chemiluminescence and TBARS were measured in heart homogenates of treated and control animals at 2-5 days after injection. Heart spontaneous emission (control value: 45 +/- 5 cps/cm2) was… CONTINUE READING