Oxidative stress in malignant melanoma enhances tumor necrosis factor-α secretion of tumor-associated macrophages that promote cancer cell invasion.

@article{Lin2013OxidativeSI,
  title={Oxidative stress in malignant melanoma enhances tumor necrosis factor-α secretion of tumor-associated macrophages that promote cancer cell invasion.},
  author={Xuzhu Lin and Wei Zheng and Jing Liu and Ya Zhang and Haohan Qin and Haochen Wu and Bin Xue and Yan Lu and Pingping Shen},
  journal={Antioxidants & redox signaling},
  year={2013},
  volume={19 12},
  pages={1337-55}
}
AIMS Malignant melanoma is well known for abundant reactive oxygen species (ROS) that exist in the primary tumor environment. Within this microenvironment, tumor-associated macrophages (TAMs) play substantial roles in multiple steps of tumor development in terms of tumor growth, invasion, and metastasis. We therefore aimed to determine whether this high-level ROS in primary melanoma is capable to promote tumor invasiveness by influencing TAM properties. Moreover, we wanted to further… CONTINUE READING