Oxidative stress in hypertensive,diabetic, and diabetic hypertensive rats.

  title={Oxidative stress in hypertensive,diabetic, and diabetic hypertensive rats.},
  author={Joseph H Friedman and Edna Peleg and Tamara Kagan and Sergei Shnizer and Talma Rosenthal},
  journal={American journal of hypertension},
  volume={16 12},
BACKGROUND Reactive oxygen species play a key role in the formation of endothelial dysfunction accompanying diabetes mellitus, hypertension, and other cardiovascular diseases. METHOD This study compares oxidative stress (OS) in Wistar-Kyoto rats (WKY), spontaneously hypertensive rats (SHR), non-insulin-dependent Cohen Diabetic rats (CDR), and Cohen Rosenthal diabetic hypertensive rats (CRDH), a unique animal model of both diabetes and hypertension. The OS was evaluated with a newly developed… CONTINUE READING


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