Oxidative stress in endothelial cell dysfunction and thrombosis

  title={Oxidative stress in endothelial cell dysfunction and thrombosis},
  author={J. Loscalzo},
  journal={Pathophysiology of Haemostasis and Thrombosis},
  pages={359 - 360}
  • J. Loscalzo
  • Published 2002
  • Medicine, Chemistry
  • Pathophysiology of Haemostasis and Thrombosis
Endothelial dysfunction (ECD) is the earliest phenotypic change in the vasculature following exposure to atherothrombotic risk factors. ECD is associated with decreased synthesis and increased oxidative inactivation of nitric oxide (NO). Critical antioxidant enzymes essential for eliminating reactive oxygen species that can inactivate NO include the superoxide dismutases, the glutathione peroxidases, catalase, and glucose-6-phosphate dehydrogenase. Deficiencies of these enzymes increase… Expand
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  • Pathophysiol Haemost Thromb
  • 2002