Oxidative stress in diabetic macrovascular disease: does homocysteine play a role?

@article{Fonseca1997OxidativeSI,
  title={Oxidative stress in diabetic macrovascular disease: does homocysteine play a role?},
  author={Vivian A. Fonseca and Andrew P Stone and Maitreyee Munshi and Bantwal Suresh Baliga and Ahmad Aljada and K Thusu and Louis Fink and Paresh Dandona},
  journal={Southern medical journal},
  year={1997},
  volume={90 9},
  pages={903-6}
}
BACKGROUND Non-insulin-dependent diabetes mellitus (NIDDM) and hyperhomocysteinemia are both associated with increased lipid peroxidation (oxidative stress). This may contribute to the accelerated vascular disease associated with these conditions. It is not known whether the coexistence of elevated homocysteine levels will stimulate oxidative stress further than that caused by diabetes alone. METHODS Plasma concentrations of thiobarbituric acid reactive substances (TBARS), an index of lipid… CONTINUE READING