Oxidative stress in desminopathies and myotilinopathies: a link between oxidative damage and abnormal protein aggregation.

@article{Janu2007OxidativeSI,
  title={Oxidative stress in desminopathies and myotilinopathies: a link between oxidative damage and abnormal protein aggregation.},
  author={Anna Janu{\'e} and Montse Oliv{\'e} and Isidro Ferrer},
  journal={Brain pathology},
  year={2007},
  volume={17 4},
  pages={377-88}
}
Myotilinopathies and desminopathies are subgroups of myofibrillar myopathies (MFM) caused by mutations in myotilin and desmin genes, respectively. They are characterized by the presence of protein aggregates in muscle cells. As oxidation of proteins facilitates their aggregation and makes them more resistant to proteolysis, the present study was geared to analyze oxidative stress in MFM. For this purpose, markers of glycoxidation, lipoxidation and nitration were examined with gel… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…