Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview.

@article{Mariani2005OxidativeSI,
  title={Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview.},
  author={Elena Mariani and Maria Cristina Polidori and Antonio Cherubini and Patrizia Mecocci},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2005},
  volume={827 1},
  pages={65-75}
}
According to the free radical theory, aging can be considered as a progressive, inevitable process partially related to the accumulation of oxidative damage into biomolecules -- nucleic acids, lipids, proteins or carbohydrates -- due to an imbalance between prooxidants and antioxidants in favor of the former. More recently also the pathogenesis of several diseases has been linked to a condition of oxidative stress. In this review we focus our attention on the evidence of oxidative stress in… CONTINUE READING
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