Oxidative stress in Ca(2+)-induced membrane permeability transition in brain mitochondria.

@article{Maciel2001OxidativeSI,
  title={Oxidative stress in Ca(2+)-induced membrane permeability transition in brain mitochondria.},
  author={Evelise N. Maciel and Anibal E Vercesi and Roger F Castilho},
  journal={Journal of neurochemistry},
  year={2001},
  volume={79 6},
  pages={1237-45}
}
Mitochondrial permeability transition (PT) is a non-selective inner membrane permeabilization, typically promoted by the accumulation of excessive quantities of Ca(2+) ions in the mitochondrial matrix. This phenomenon may contribute to neuronal cell death under some circumstances, such as following brain trauma and hypoglycemia. In this report, we show that Ca(2+)-induced brain mitochondrial PT was stimulated by Na(+) (10 mM) and totally prevented by the combination of ADP and cyclosporin A… CONTINUE READING

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