Oxidative stress in Alzheimer's disease: are we connecting the dots?

@article{Rosini2014OxidativeSI,
  title={Oxidative stress in Alzheimer's disease: are we connecting the dots?},
  author={Michela Rosini and Elena Simoni and Andrea Milelli and Anna Minarini and Carlo Melchiorre},
  journal={Journal of medicinal chemistry},
  year={2014},
  volume={57 7},
  pages={
          2821-31
        }
}
Redox impairment is a prominent feature of Alzheimer's disease (AD). It has led to the "oxidative stress hypothesis", which proposes antioxidants as beneficial therapeutic tools in AD treatment. To date, a wide variety of antioxidants have been examined as neuroprotectants. However, success has been elusive in clinical trials. Several factors have contributed to this failure, including the complexity of the redox system in vivo. Potentially critical aspects include the fine-tuned equilibrium… CONTINUE READING
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