Oxidative stress drives disulfide bond formation between basic helix-loop-helix transcription factors.

Abstract

Basic helix-loop-helix (bHLH) transcription factors including Twist1 and E2a proteins regulate essential processes. These factors bind DNA as homo- or heterodimers and the choice of binding partners determines their functional output. To investigate potential regulators of bHLH dimerization, cells were exposed to the oxidative agent hydrogen peroxide (H(2)O… (More)
DOI: 10.1002/jcb.22415

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