Oxidative stress disrupts oligodendrocyte maturation.

@article{French2009OxidativeSD,
  title={Oxidative stress disrupts oligodendrocyte maturation.},
  author={Heather Morein French and Mary Reid and Polina Mamontov and Rebecca A. Simmons and Judith B. Grinspan},
  journal={Journal of neuroscience research},
  year={2009},
  volume={87 14},
  pages={3076-87}
}
Periventricular white matter injury (PWMI) is the leading cause of chronic neurologic injury among survivors of preterm birth. The hallmark of PWMI is hypomyelination and a lack of mature, myelinating oligodendrocytes. Oligodendrocytes undergo a well-characterized lineage progression from neural stem cell to mature oligodendrocyte. Oligodendrocyte precursors have increased susceptibility to oxidative and free radical-mediated injury compared with mature oligodendrocytes as a result of lower… CONTINUE READING

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