Oxidative stress developed during the reperfusion of ischemic myocardium induces apoptosis.

@article{Maulik1998OxidativeSD,
  title={Oxidative stress developed during the reperfusion of ischemic myocardium induces apoptosis.},
  author={Nilanjana Maulik and Tetsuya Yoshida and Dipak Kumar Das},
  journal={Free radical biology & medicine},
  year={1998},
  volume={24 5},
  pages={869-75}
}
Apoptosis or programmed cell death is a genetically controlled response for cells to commit suicide and, is associated with DNA fragmentation or laddering. The common inducers of apoptosis include oxygen free radicals/oxidative stress and Ca2+ which are also implicated in the pathogenesis of myocardial ischemic reperfusion injury. To examine whether ischemic reperfusion injury is mediated by apoptotic cell death, isolated perfused rat hearts were subjected to 15, 30 or 60 min of ischemia as… CONTINUE READING
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