Oxidative stress controls the choice of alternative last exons via a Brahma–BRCA1–CstF pathway

@article{Fontana2017OxidativeSC,
  title={Oxidative stress controls the choice of alternative last exons via a Brahma–BRCA1–CstF pathway},
  author={Gabriele A Fontana and Aurora Rigamonti and Silvia C. Lenzken and Giuseppe Filosa and Reinaldo Alvarez and Raffaele Adolfo Calogero and Marco Emilio Bianchi and Silvia M.L. Barabino},
  journal={Nucleic Acids Research},
  year={2017},
  volume={45},
  pages={902 - 914}
}
Alternative splicing of terminal exons increases transcript and protein diversity. How physiological and pathological stimuli regulate the choice between alternative terminal exons is, however, largely unknown. Here, we show that Brahma (BRM), the ATPase subunit of the hSWI/SNF chromatin-remodeling complex interacts with BRCA1/BARD1, which ubiquitinates the 50 kDa subunit of the 3′ end processing factor CstF. This results in the inhibition of transcript cleavage at the proximal poly(A) site and… 

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