Oxidative stress contributes to sex differences in angiotensin II-mediated hypertension in spontaneously hypertensive rats.

@article{Bhatia2012OxidativeSC,
  title={Oxidative stress contributes to sex differences in angiotensin II-mediated hypertension in spontaneously hypertensive rats.},
  author={Kanchan Bhatia and Ahmed A. Elmarakby and Azza B El-Remessy and J. Charlie Sullivan},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2012},
  volume={302 2},
  pages={R274-82}
}
NADPH oxidase has been implicated in ANG II-induced oxidative stress and hypertension in males; however, the contribution of oxidative stress to ANG II hypertension in females is unknown. In the present study, we tested the hypothesis that greater antioxidant capacity in female spontaneously hypertensive rats (SHR) blunts ANG II-induced oxidative stress and hypertension relative to males. Whole body and renal cortical oxidative stress levels were assessed in female and male SHR left untreated… CONTINUE READING