Oxidative stress contributes to arsenic-induced telomere attrition, chromosome instability, and apoptosis.

@article{Liu2003OxidativeSC,
  title={Oxidative stress contributes to arsenic-induced telomere attrition, chromosome instability, and apoptosis.},
  author={Lin Liu and James Robert Trimarchi and Paula Andrea Navarro and Maria A Blasco and David Lawrence Keefe},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 34},
  pages={
          31998-2004
        }
}
The environmental contaminant arsenic causes cancer, developmental retardation, and other degenerative diseases and, thus, is a serious health concern worldwide. Paradoxically, arsenic also may serve as an anti-tumor therapy, although the mechanisms of its antineoplastic effects remain unclear. Arsenic exerts its toxicity in part by generating reactive oxygen species. We show that arsenic-induced oxidative stress promotes telomere attrition, chromosome end-to-end fusions, and apoptotic cell… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 85 CITATIONS, ESTIMATED Infinity% COVERAGE

85 Citations

05'03'06'10'14'18
Citations per Year
Semantic Scholar estimates that this publication has 85 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
SHOWING 1-3 OF 3 REFERENCES

Oncologist 6, 3–10 Arsenic-induced Telomere Dysfunction

  • S. Waxman, K. C. Anderson
  • N A N K A I U N IV E R IT Y on Jne 5,
  • 2001
1 Excerpt

Cancer Epidemiol

  • A. Schatzkin, J. Lubin, B. L. Mao, J. Y. Rao, M. McAdams, X. Z. Xuan
  • Biomark . Prev .
  • 1994

In Vitro Cell

  • I. C. Ho
  • Dev . Biol .
  • 1989

Similar Papers

Loading similar papers…