Oxidative stress causes a general, calcium-dependent degradation of mitochondrial polynucleotides.

Abstract

Oxidative stress has many effects on biological cells, including the modulation of gene expression. Reactive oxygen species are known to up-regulate and down-regulate RNA expression in prokaryotic and eukaryotic cells. We have previously reported that a preferential and calcium-dependent down-regulation of mitochondrial RNAs occurs when HA-1 hamster… (More)

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@article{Crawford1998OxidativeSC, title={Oxidative stress causes a general, calcium-dependent degradation of mitochondrial polynucleotides.}, author={Dean Crawford and N E Abramova and Karen Davies}, journal={Free radical biology & medicine}, year={1998}, volume={25 9}, pages={1106-11} }