Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium.

Abstract

The objective of our study was to examine testicular toxicity of cadmium (Cd), focusing on oxidative stress (OS), essential metals and androgenic status and morphological changes. Male Wistar rats [controls and four Cd-subgroups (n = 6) organized according to the exposure (1, 3, 10 and 21 days)] were intraperitoneally (i.p.) treated with 1 mg CdCl2/kg/day. Testicular Cd deposition was noticed from the 1st day. After 10 and 21 days, copper (Cu) and iron (Fe) increased by 60-109% and 43-67%, respectively, while zinc (Zn) decreased by 24-33%. During 1-21 days of the exposure, decrease in testicular total superoxide dismutase (SOD) and total glutathione-s-transferase (GST) activities occurred gradually by 30-78% and 15-84%, respectively, while superoxide anion radical (O2(-)) increased gradually by 114-271%. After 10-21 days, decrease in testicular catalase (CAT) activity appeared by 13-31%. After 21 days, malondialdehyde (MDA) decreased by 44% and the ratio of oxidized glutathione/reduced glutathione (GSSG/GSH) increased by 130% in testes of the rats exposed to Cd. Additionally, decreased testicular testosterone level and the relative testes mass, along with induced microscopic and macroscopic changes were occured, what can be explained as the consequence of instantly developed OS, impaired essential metals status and Cd testicular deposition.

DOI: 10.1016/j.fct.2015.09.004

Cite this paper

@article{Djuric2015OxidativeSB, title={Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium.}, author={Ana Djuric and Aida Begic and Borko Gobeljic and Ivan Stanojevic and Milica B Ninkovi{\'c} and Danilo V Vojvodic and Ana Panteli{\'c} and Goran Zebic and Vera Proki{\'c} and Bratislav Dejanovic and Ivana Stojanovic and Marina Pavlica and Du{\vs}an Djuki{\'c} and Luciano Saso and Dragan Djurdjevi{\'c} and Milo{\vs} D. Pavlovi{\'c} and Aleksandra S Topic and Dragana Vujanovi{\'c} and Ivana Stevnovic and Mirjana M. Djukic}, journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association}, year={2015}, volume={86}, pages={25-33} }