Oxidative stress and upregulation of mitochondrial biogenesis genes in mitochondrial DNA-depleted HeLa cells.

@article{Miranda1999OxidativeSA,
  title={Oxidative stress and upregulation of mitochondrial biogenesis genes in mitochondrial DNA-depleted HeLa cells.},
  author={Soledad Miranda and Rocio E. Foncea and Javier Guerrero and Federico M Leighton},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={258 1},
  pages={
          44-9
        }
}
The signaling mechanism through which deficitary mitochondrial function would activate nuclear genes required for mitochondrial biogenesis, has not been established. To explore the hypothesis that reactive oxygen species (ROS), a mitochondrial product, constitute part of the mitochondria-nuclei signaling pathway, we obtained HeLa cells depleted of mitochondrial DNA (rho0 cells) through exposure to ethidium bromide. We found evidences of oxidative stress in rho0 cells, employing a fluorescent… CONTINUE READING
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