Oxidative stress and transcriptional regulation in Alzheimer disease.

  title={Oxidative stress and transcriptional regulation in Alzheimer disease.},
  author={Qingli Shi and Gary E Gibson},
  journal={Alzheimer disease and associated disorders},
  volume={21 4},
Alzheimer disease (AD) is defined by progressive impairments in memory and cognition and by the presence of extracellular neuritic plaques and intracellular neurofibrillary tangles. However, oxidative stress and impaired mitochondrial function always accompany AD. Mitochondria are a major site of production of free radicals [ie, reactive oxygen species (ROS)] and primary targets of ROS. ROS are cytotoxic, and evidence of ROS-induced damage to cell membranes, proteins, and DNA in AD is… CONTINUE READING