Oxidative stress and the regulation of complement activation in human glaucoma.

@article{Tezel2010OxidativeSA,
  title={Oxidative stress and the regulation of complement activation in human glaucoma.},
  author={G{\"u}lg{\"u}n Tezel and Xiangjun Yang and Cheng Si Luo and Angela D Kain and David W. Powell and Markus H. Kuehn and Henry J. Kaplan},
  journal={Investigative ophthalmology & visual science},
  year={2010},
  volume={51 10},
  pages={5071-82}
}
PURPOSE As part of ongoing studies on proteomic alterations during glaucomatous neurodegeneration, this study focused on the complement system. METHODS Human retinal protein samples obtained from donor eyes with (n = 10) or without (n = 10) glaucoma were analyzed by a quantitative proteomic approach using mass spectrometry. Cellular localization of protein expression for different complement components and regulators were also determined by immunohistochemical analysis of an additional group… CONTINUE READING